| | | | Very truly yours, | |
| | | | ![]() Angelos M. Stergiou, M.D., Sc.D. h.c. President and Chief Executive Officer | |
| | | | By Order of the Board of Directors, | |
| | | | ![]() Angelos M. Stergiou, M.D., Sc.D. h.c. | |
| | | | President and Chief Executive Officer | |
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| ![]() ![]() | | | By Internet: | | |||
| ![]() ![]() | | | By Telephone: | | |||
| ![]() ![]() | | | By Proxy by Mail: | |
| Proposal 1: | | | To elect two (2) Class II directors to serve on the Company’s Board of Directors for a three-year term expiring in 2027. | |
| Proposal 2: | | | To ratify the appointment by our Audit Committee of Moss Adams LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2024. | |
| Proposal 3: | | | To approve, on a non-binding advisory basis, the compensation of our named executive officers. | |
Name of Beneficial Owner | | Number | | Percentage of Shares Beneficially Owned | | | Number | | Percentage of Shares Beneficially Owned | | ||||||||||||||||
5% or Greater Stockholders: | | | | | | | | | | | | |||||||||||||||
Entities affiliated with Anson Advisors, Inc and Anson Funds Management LP | | | | 4,286,619(1) | | | | | 7.6% | | | |||||||||||||||
Directors and Executive Officers: | | | | | | | | | | | | |||||||||||||||
Angelos M. Stergiou, President, Chief Executive Officer and Director | | | | 98,268(1) | | | | | * | | | | | | 402,415(2) | | | | | * | | | ||||
Barbara A. Wood, Executive Vice President, General Counsel and Corporate Secretary | | | | 34,919(2) | | | | | * | | | |||||||||||||||
Dragan Cicic, Senior Vice President, Clinical Development | | | | 36,755(3) | | | | | * | | | |||||||||||||||
Barbara A. Wood, Former Executive Vice President, General Counsel and Corporate Secretary | | | | 142,717(3) | | | | | * | | | |||||||||||||||
John T. Burns, Senior Vice President, Chief Financial Officer | | | | 98,866(4) | | | | | | | | |||||||||||||||
Jane Wasman, Chair of the Board | | | | 14,830(5) | | | | | * | | | | | | 35,855(5) | | | | | * | | | ||||
David L. Scheinberg, Director | | | | 15,012(4) | | | | | * | | | |||||||||||||||
Robert Van Nostrand, Director | | | | 14,830(5) | | | | | * | | | |||||||||||||||
David A. Scheinberg, Director | | | | 36,037(6) | | | | | * | | | |||||||||||||||
Robert L. Van Nostrand, Director | | | | 35,855(5) | | | | | * | | | |||||||||||||||
John Varian, Director | | | | 14,830(5) | | | | | * | | | | | | 35,855(5) | | | | | * | | | ||||
Katherine Bach Kalin, Director | | | | 32,900(7) | | | | | * | | | |||||||||||||||
All current executive officers and directors as a group (7 persons) | | | | 229,444 | | | | | 1.1 | | | | | | 677,783 | | | | | 1.2 | | |
Name | | | Age | | | Position | | | Term Expires | | | Audit Committee | | | Compensation Committee | | | Nominating And Corporate Governance Committee | | | Science Committee | | ||||||||||||||||||
Jane Wasman | | | | | 65 | | | | Chair of the Board | | | | | 2023 | | | | | | ✓ | | | | | | ✓ | | | | | | ✓* | | | | | | | | |
Angelos M. Stergiou | | | | | 46 | | | | Director, President and Chief Executive Officer | | | | | 2022 | | | | | | | | | | | | | | | | | | | | | | | | ✓ | | |
David A. Scheinberg | | | | | 66 | | | | Director | | | | | 2024 | | | | | | | | | | | | ✓ | | | | | | | | | | | | ✓* | | |
Robert L. Van Nostrand | | | | | 65 | | | | Director | | | | | 2023 | | | | | | ✓ | | | | | | ✓* | | | | | | ✓ | | | | | | | | |
John Varian | | | | | 61 | | | | Director | | | | | 2022 | | | | | | ✓* | | | | | | | | | | | | ✓ | | | | | | ✓ | | |
Name | | | Age | | | Position | | | Term Expires | | | Audit Committee | | | Compensation Committee | | | Nominating and Corporate Governance Committee | | | Science Committee | | ||||||||||||
Jane Wasman | | | 67 | | | Chair of the Board | | | 2026 | | | | | ✔ | | | | | | | | | | | | ✔* | | | | | | | | |
Angelos M. Stergiou | | | 48 | | | Director, President and Chief Executive Officer | | | 2025 | | | | | | | | | | | | | | | | | | | | | | | ✔ | | |
David A. Scheinberg | | | 68 | | | Director | | | 2024 | | | | | | | | | | | ✔ | | | | | | | | | | | | ✔* | | |
Robert L. Van Nostrand | | | 67 | | | Director | | | 2026 | | | | | ✔* | | | | | | | | | | | | ✔ | | | | | | | | |
John Varian | | | 64 | | | Director | | | 2025 | | | | | ✔ | | | | | | ✔* | | | | | | | | | | | | ✔ | | |
Katherine Bach Kalin | | | 61 | | | Director | | | 2024 | | | | | | | | | | | ✔ | | | | | | ✔ | | | | | | | | |
Name | | | Age | | | Position with the Company | |
Angelos M. Stergiou, M.D., Sc.D. h.c. | | | | | President, Chief Executive Officer and Director | | |
John T. Burns | | | |||||
| | Senior Vice President, Chief | |
| | | Year | | | Salary ($) | | | Non-Equity Incentive Plan Compensation ($)(3) | | | Bonus ($) | | | Option Awards ($)(1) | | | Stock Awards ($)(2) | | | All Other Compensation ($) | | | Total ($) | | ||||||||||||||||||||||||
Angelos M. Stergiou, M.D., Sc.D. h.c. | | | | | 2021 | | | | | | 565,100 | | | | | | 280,000 | | | | | | — | | | | | | 827,887 | | | | | | 158,000 | | | | | | 2,930(6) | | | | | | 1,833,917 | | |
President and Chief Executive Officer | | | | | 2020 | | | | | | 540,750 | | | | | | 283,894 | | | | | | — | | | | | | 107,800 | | | | | | 179,550 | | | | | | 2,930(6) | | | | | | 1,114,924 | | |
Barbara A. Wood, Esq. | | | | | 2021 | | | | | | 404,700 | | | | | | 152,000 | | | | | | — | | | | | | 330,107 | | | | | | 63,000 | | | | | | 14,530(7) | | | | | | 964,337 | | |
Executive Vice President, General Counsel and Corporate Secretary | | | | | 2020 | | | | | | 387,230 | | | | | | 165,734 | | | | | | 10,000(4) | | | | | | 38,500 | | | | | | 66,150 | | | | | | 14,330(8) | | | | | | 681,944 | | |
Dragan Cicic, M.D.(5) | | | | | 2021 | | | | | | 339,900 | | | | | | 112,000 | | | | | | — | | | | | | 330,107 | | | | | | 63,000 | | | | | | 14,530(7) | | | | | | 859,537 | | |
Senior Vice President, Clinical Development | | | | | 2020 | | | | | | 302,550 | | | | | | 91,658 | | | | | | — | | | | | | 53,900 | | | | | | 47,250 | | | | | | 13,694(8) | | | | | | 509,052 | | |
Name | | | Year | | | Salary ($) | | | Non-Equity Incentive Plan Compensation ($)(3) | | | Bonus ($) | | | Option Awards ($)(1) | | | Stock Awards ($)(2) | | | All Other Compensation ($) | | | Total ($) | | ||||||||||||||||||||||||
Angelos M. Stergiou, M.D., Sc.D. h.c. President and Chief Executive Officer | | | | | 2023 | | | | | | 625,000 | | | | | | 275,000 | | | | | | — | | | | | | 654,675 | | | | | | 193,720 | | | | | | 4,243(5) | | | | | | 1,752,638 | | |
| | | 2022 | | | | | | 593,500 | | | | | | 326,425 | | | | | | — | | | | | | 795,300 | | | | | | 234,960 | | | | | | 2,060(5) | | | | | | 1,952,245 | | | ||
Barbara Wood, Esq. Former Executive Vice President, General Counsel and Corporate Secretary | | | | | 2023 | | | | | | 442,000 | | | | | | 146,744 | | | | | | — | | | | | | 240,800 | | | | | | 66,800 | | | | | | 17,576(7) | | | | | | 913,920 | | |
| | | 2022 | | | | | | 425,000 | | | | | | 173,400 | | | | | | 20,000(4) | | | | | | 234,975 | | | | | | 69,420 | | | | | | 14,260(8) | | | | | | 937,055 | | | ||
John T. Burns Senior Vice President, Chief Financial Officer | | | | | 2023 | | | | | | 365,000 | | | | | | 125,560 | | | | | | — | | | | | | 225,750 | | | | | | 66,800 | | | | | | 14,598(7) | | | | | | 797,708 | | |
| | | 2022 | | | | | | 310,000 | | | | | | 111,800 | | | | | | — | | | | | | 173,520 | | | | | | 52,264 | | | | | | 13,260(8) | | | | | | 659,844 | | |
Name | | | Grant Date | | | Number of Securities Underlying Unexercised Options Exercisable | | | Number of Securities Underlying Unexercised Options (#) Unexercisable(1) | | | Option Exercise Price ($)(2) | | | Option Expiration Date | | | Number of Shares or Units of Stock That Have Not Vested (#)(3) | | | Market Value of Shares or Units of Stock That Have Not Vested ($)(4) | | |||||||||||||||||||||
Angelos M. Stergiou | | | | | 3/13/2018 | | | | | | 1,781 | | | | | | 119 | | | | | $ | 262.00 | | | | | | 3/13/2028 | | | | | | — | | | | | | — | | |
| | | | | 3/18/2019 | | | | | | 5,844 | | | | | | 2,656 | | | | | $ | 69.00 | | | | | | 3/18/2029 | | | | | | — | | | | | | — | | |
| | | | | 3/12/2020 | | | | | | 30,625 | | | | | | 39,375 | | | | | $ | 1.89 | | | | | | 3/12/2030 | | | | | | — | | | | | | — | | |
| | | | | 3/12/2020 | | | | | | — | | | | | | — | | | | | $ | — | | | | | | — | | | | | | 95,000 | | | | | $ | 525,350 | | |
| | | | | 3/4/2021 | | | | | | — | | | | | | 118,500 | | | | | $ | 8.00 | | | | | | 3/4/2031 | | | | | | — | | | | | | — | | |
| | | | | 3/4/2021 | | | | | | — | | | | | | — | | | | | $ | — | | | | | | — | | | | | | 14,812 | | | | | $ | 81,910 | | |
Barbara A. Wood | | | | | 3/13/2018 | | | | | | 938 | | | | | | 62 | | | | | $ | 255.00 | | | | | | 3/14/2028 | | | | | | — | | | | | | — | | |
| | | | | 3/18/2019 | | | | | | 2,269 | | | | | | 1,031 | | | | | $ | 69.00 | | | | | | 3/18/2029 | | | | | | — | | | | | | — | | |
| | | | | 3/12/2020 | | | | | | 10,938 | | | | | | 14,062 | | | | | $ | 1.89 | | | | | | 3/12/2030 | | | | | | — | | | | | | — | | |
| | | | | 3/12/2020 | | | | | | — | | | | | | — | | | | | $ | — | | | | | | — | | | | | | 35,000 | | | | | $ | 193,550 | | |
| | | | | 3/4/2021 | | | | | | — | | | | | | 47,250 | | | | | $ | 8.00 | | | | | | 3/4/2031 | | | | | | — | | | | | | — | | |
| | | | | 3/4/2021 | | | | | | — | | | | | | — | | | | | $ | — | | | | | | — | | | | | | 5,906 | | | | | $ | 32,660 | | |
Dragan Cicic | | | | | 3/12/2020 | | | | | | 15,313 | | | | | | 19,687 | | | | | $ | 1.89 | | | | | | 3/12/2030 | | | | | | | | | | | | | | |
| | | | | 3/12/2020 | | | | | | — | | | | | | — | | | | | $ | — | | | | | | — | | | | | | 25,000 | | | | | $ | 138,250 | | |
| | | | | 3/4/2021 | | | | | | — | | | | | | 47,250 | | | | | $ | 8.00 | | | | | | 3/4/2031 | | | | | | — | | | | | | — | | |
| | | | | 3/4/2021 | | | | | | — | | | | | | — | | | | | $ | — | | | | | | — | | | | | | 5,906 | | | | | $ | 32,660 | | |
Name | | | Grant Date | | | Number of Securities Underlying Unexercised Options Exercisable | | | Number of Securities Underlying Unexercised Options (#) Unexercisable(1) | | | Option Exercise Price ($)(2) | | | Option Expiration Date | | | Number of Shares or Units of Stock That Have Not Vested (#)(3) | | | Market Value of Shares or Units of Stock That Have Not Vested ($)(4) | | |||||||||||||||||||||
Angelos M. Stergiou | | | | | 03/13/2018 | | | | | | 1,900 | | | | | | — | | | | | $ | 262.00 | | | | | | 03/13/2028 | | | | | | — | | | | | | — | | |
| | | 03/18/2019 | | | | | | 8,500 | | | | | | — | | | | | $ | 69.00 | | | | | | 03/18/2029 | | | | | | — | | | | | | — | | | ||
| | | 03/12/2020 | | | | | | 65,625 | | | | | | 4,375 | | | | | $ | 1.89 | | | | | | 03/12/2030 | | | | | | — | | | | | | — | | | ||
| | | 03/12/2020 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | 95,000 | | | | | $ | 100,700 | | | ||
| | | 03/04/2021 | | | | | | 81,469 | | | | | | 37,031 | | | | | $ | 8.00 | | | | | | 03/04/2031 | | | | | | — | | | | | | — | | | ||
| | | 03/04/2021 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | 4,937 | | | | | $ | 5,233 | | | ||
| | | 01/31/2022 | | | | | | 79,063 | | | | | | 85,938 | | | | | $ | 5.34 | | | | | | 01/31/2032 | | | | | | — | | | | | | — | | | ||
| | | 01/31/2022 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | 22,000 | | | | | $ | 23,320 | | | ||
| | | 02/02/2023 | | | | | | — | | | | | | 217,500 | | | | | $ | 3.34 | | | | | | 02/02/2033 | | | | | | — | | | | | | — | | | ||
| | | 02/02/2023 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | 43,500 | | | | | $ | 46,110 | | | ||
Barbara A. Wood | | | | | 03/14/2018 | | | | | | 1,000 | | | | | | — | | | | | $ | 255.00 | | | | | | 03/14/2028 | | | | | | — | | | | | | — | | |
| | | 03/18/2019 | | | | | | 3,300 | | | | | | — | | | | | $ | 69.00 | | | | | | 03/18/2029 | | | | | | — | | | | | | — | | | ||
| | | 03/12/2020 | | | | | | 23,438 | | | | | | 1,563 | | | | | $ | 1.89 | | | | | | 03/12/2030 | | | | | | — | | | | | | — | | | ||
| | | 03/12/2020 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | 35,000 | | | | | $ | 37,100 | | | ||
| | | 03/04/2021 | | | | | | 32,484 | | | | | | 14,766 | | | | | $ | 8.00 | | | | | | 03/04/2031 | | | | | | — | | | | | | — | | | ||
| | | 03/04/2021 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | 1,968 | | | | | $ | 2,086 | | | ||
| | | 01/31/2022 | | | | | | 23,359 | | | | | | 25,391 | | | | | $ | 5.34 | | | | | | 01/31/2032 | | | | | | — | | | | | | — | | | ||
| | | 01/31/2022 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | 6,500 | | | | | $ | 6,890 | | | ||
| | | 02/02/2023 | | | | | | — | | | | | | 80,000 | | | | | $ | 3.34 | | | | | | 02/02/2033 | | | | | | — | | | | | | — | | | ||
| | | 02/02/2023 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | 15,000 | | | | | $ | 15,900 | | | ||
John T. Burns | | | | | 03/13/2018 | | | | | | 400 | | | | | | — | | | | | $ | 262.00 | | | | | | 03/14/2028 | | | | | | — | | | | | | — | | |
| | | 03/18/2019 | | | | | | 1,800 | | | | | | — | | | | | $ | 69.00 | | | | | | 03/18/2029 | | | | | | — | | | | | | — | | | ||
| | | 03/12/2020 | | | | | | 9,375 | | | | | | 625 | | | | | $ | 1.89 | | | | | | 03/12/2030 | | | | | | — | | | | | | — | | | ||
| | | 03/12/2020 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | 15,000 | | | | | $ | 15,900 | | | ||
| | | 03/04/2021 | | | | | | 11,859 | | | | | | 5,391 | | | | | $ | 8.00 | | | | | | 03/04/2031 | | | | | | — | | | | | | — | | | ||
| | | 03/04/2021 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | 718 | | | | | $ | 761 | | | ||
| | | 01/31/2022 | | | | | | 17,250 | | | | | | 18,750 | | | | | $ | 5.34 | | | | | | 01/31/2032 | | | | | | — | | | | | | — | | | ||
| | | 01/31/2022 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | 4,800 | | | | | $ | 5,088 | | | ||
| | | 02/02/2023 | | | | | | — | | | | | | 75,000 | | | | | $ | 3.34 | | | | | | 02/02/2033 | | | | | | — | | | | | | — | | | ||
| | | 02/02/2023 | | | | | | — | | | | | | — | | | | | | — | | | | | | — | | | | | | 15,000 | | | | | $ | 15,900 | | |
Year(a) | | | Summary Compensation Table Total for PEO(b) | | | Compensation Actually Paid to PEO(c) | | | Average Summary Compensation Table Total for Non-PEO NEOs(d) | | | Average Compensation Actually Paid to Non-PEO NEOs(e) | | | Value of Initial Fixed $100 Investment Based On Total Shareholder Return(f) | | | Net Loss (thousands)(g) | | ||||||||||||||||||
2023 | | | | $ | 1,752,638 | | | | | $ | 801,284 | | | | | $ | 855,814 | | | | | | 536,561 | | | | | | 44.92 | | | | | $ | (37,340) | | |
2022 | | | | $ | 1,952,245 | | | | | $ | 667,297 | | | | | $ | 995,219 | | | | | | 514,536 | | | | | | 42.68 | | | | | $ | (41,301) | | |
2021 | | | | $ | 1,833,917 | | | | | $ | 1,615,812 | | | | | $ | 911,937 | | | | | | 935,768 | | | | | | 95.18 | | | | | $ | (20,699) | | |
Year | | | Reported Summary Comp Table Total for PEO | | | Reported Value of Equity Awards(1) | | | Equity Award Adjustments(2) | | | Compensation Actually Paid to PEO | | ||||||||||||
2023 | | | | $ | 1,752,638 | | | | | $ | (848,395) | | | | | $ | (102,959) | | | | | $ | 801,284 | | |
2022 | | | | $ | 1,952,245 | | | | | $ | (1,030,260) | | | | | $ | (254,688) | | | | | $ | 667,297 | | |
2021 | | | | $ | 1,833,917 | | | | | $ | (985,887) | | | | | $ | 767,782 | | | | | $ | 1,615,812 | | |
Year | | | Year End Fair Value of Outstanding and Unvested Equity Awards Granted in the Year | | | Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards Granted in Prior Years | | | Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year | | | Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year | | | Total Equity Award Adjustments | | |||||||||||||||
2023 | | | | $ | 238,628 | | | | | $ | (315,187) | | | | | $ | 15,660 | | | | | $ | (42,060) | | | | | $ | (102,959) | | |
2022 | | | | $ | 413,468 | | | | | $ | (606,744) | | | | | $ | 28,600 | | | | | $ | (90,012) | | | | | $ | (254,688) | | |
2021 | | | | $ | 666,308 | | | | | $ | (46,816) | | | | | $ | 31,057 | | | | | $ | 117,233 | | | | | $ | 767,782 | | |
Year | | | Average Reported Summary Compensation Table Total for Non-PEO NEOs | | | Average Reported Value of Equity Awards(1) | | | Average Equity Award Adjustments(2) | | | Average Compensation Actually Paid to Non-PEO NEOs | | ||||||||||||
2023 | | | | $ | 855,814 | | | | | $ | (300,075) | | | | | $ | (19,178) | | | | | $ | 536,561 | | |
2022 | | | | $ | 995,219 | | | | | $ | (388,187) | | | | | $ | (92,496) | | | | | $ | 514,536 | | |
2021 | | | | $ | 911,937 | | | | | $ | (393,107) | | | | | $ | 416,938 | | | | | $ | 935,768 | | |
Year | | | Average Year End Fair Value of Outstanding and Unvested Equity Awards Granted in the Year | | | Year over Year Average Change in Fair Value of Outstanding and Unvested Equity Awards Granted in Prior Years | | | Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year | | | Year over Year Average Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year | | | Total Average Equity Award Adjustments | | |||||||||||||||
2023 | | | | $ | 69,008 | | | | | $ | (82,509) | | | | | $ | 5,400 | | | | | $ | (11,077) | | | | | $ | (19,178) | | |
2022 | | | | $ | 163,465 | | | | | $ | (229,926) | | | | | $ | 8,450 | | | | | $ | (34,484) | | | | | $ | (92,496) | | |
2021 | | | | $ | 265,680 | | | | | $ | 82,467 | | | | | $ | 12,383 | | | | | $ | 56,408 | | | | | $ | 416,938 | | |
Name | | Fees Earned or Paid in Cash ($)(1) | | Option Awards ($)(2) | | Total ($)(3) | | | Fees Earned or Paid in Cash ($)(1) | | Option Awards ($)(2) | | Stock Awards ($)(3) | | Total ($)(4) | | ||||||||||||||||||||||||||||
Jane Wasman | | | | 90,000 | | | | | 51,505 | | | | | 141,505 | | | | | | 99,780 | | | | | 28,151 | | | | | 8,350 | | | | | 136,281 | | | |||||||
Robert L. Van Nostrand | | | | 61,375 | | | | | 51,505 | | | | | 114,255 | | | | | | 69,780 | | | | | 28,151 | | | | | 8,350 | | | | | 106,281 | | | |||||||
John Varian | | | | 62,750 | | | | | 51,505 | | | | | 112,880 | | | | | | 74,000 | | | | | 28,151 | | | | | 8,350 | | | | | 110,501 | | | |||||||
David A. Scheinberg | | | | 47,500 | | | | | 51,505 | | | | | 99,005 | | | | | | 66,000 | | | | | 28,151 | | | | | 8,350 | | | | | 102,501 | | | |||||||
Katherine Bach Kalin | | | | 56,000 | | | | | 28,151 | | | | | 8,350 | | | | | 92,501 | | |
Compensation Category | | Amount | | | Amount | | ||||||||
Annual Base Compensation | | | $ | 40,000 | | | | | $ | 40,000 | | | ||
Additional Non-Executive Chair Compensation | | | $ | 30,000 | | | | | $ | 30,000 | | | ||
Additional Committee Chair Compensation: | | | | | | | | | | | | | ||
Audit | | | $ | 18,000 | | | | | $ | 18,000 | | | ||
Compensation | | | $ | 18,000 | | | | | $ | 18,000 | | | ||
Nominations and Governance | | | $ | 18,000 | | | ||||||||
Science (f/k/a Research & Development) | | | $ | 18,000 | | | ||||||||
Nominating and Corporate Governance | | | $ | 18,000 | | | ||||||||
Science | | | $ | 18,000 | | | ||||||||
Additional Committee Membership Compensation: | | | | | | | | | $ | 18,000 | | | ||
Audit | | | $ | 8,000 | | | | | $ | 8,000 | | | ||
Compensation | | | $ | 8,000 | | | | | $ | 8,000 | | | ||
Nominations and Governance | | | $ | 8,000 | | | ||||||||
Nominating and Corporate Governance | | | $ | 8,000 | | | ||||||||
Science | | | $ | 8,000 | | | | | $ | 8,000 | | |
Plan Category | | Number of Securities to be Issued upon Exercise of Outstanding Options, Warrants and Rights | | Weighted Average Exercise Price of Outstanding Options, Warrants and Rights | | Number of Securities Remaining Available for Future Issuance under Equity Compensation Plans (Excluding Securities Reflected in Previous Columns) | | | Number of Securities to be Issued upon Exercise of Outstanding Options, Warrants and Rights | | Weighted Average Exercise Price of Outstanding Options, Warrants and Rights | | Number of Securities Remaining Available for Future Issuance under Equity Compensation Plans (Excluding Securities Reflected in Previous Columns) | | ||||||||||||||||||||||||
Equity compensation plans approved by security holders | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | ||||||
2017 Equity Incentive Plan | | | | 21,520 | | | | $ | 112.85 | | | | | — | | | | | | 21,520 | | | | $ | 112.85 | | | | | — | | | ||||||
2019 Equity Incentive Plan | | | | 512,250 | | | | $ | 5.77 | | | | | 449,476 | | | ||||||||||||||||||||||
Restricted Stock units | | | | 200,280 | | | | | N/A | | | | | — | | | ||||||||||||||||||||||
2017 Employee Stock Purchase Plan | | | | — | | | | | N/A | | | | | 11,302 | | | ||||||||||||||||||||||
2023 Amended and Restated Equity Incentive Plan Stock | | | | 1,923,424 | | | | $ | 4.47(1) | | | | | 3,950,528 | | | ||||||||||||||||||||||
2021 Employee Stock Purchase Plan | | | | — | | | | | N/A | | | | | 300,000 | | | | | | — | | | | | N/A | | | | | 183,457 | | | ||||||
Equity compensation plans not approved by security holders | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | ||||||
None | | | | — | | | | | — | | | | | — | | | | | | | | | | | | | | | | | | | ||||||
Total | | | | 734,050 | | | | $ | 10.09 | | | | | 760,778 | | | | | | 21,520 | | | | | 112.85 | | | | | — | | |
| | 2020 | | 2021 | | | 2023 | | 2022 | | ||||||||||||||||
| | (in thousands) | | | (in thousands) | | ||||||||||||||||||||
Audit Fees(1) | | | $ | 373 | | | | $ | 403 | | | | | $ | 457 | | | | $ | 416 | | | ||||
Audit-related Fees(2) | | | | 105 | | | | | 157 | | | | | | 103 | | | | | 187 | | | ||||
Tax Fees(3) | | | | 50 | | | | | 37 | | | | | | 33 | | | | | 37 | | | ||||
All Other Fees | | | | — | | | | | — | | | | | | — | | | | | — | | | ||||
Total Fees | | | $ | 528 | | | | $ | 597 | | | | | $ | 593 | | | | $ | 640 | | |